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Nat Cell Biol. 2015 Mar;17(3):204-11. doi: 10.1038/ncb3108.

In vivo reprogramming for tissue repair.

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INSERM U836, F-38000 Grenoble, France and Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F-38000 Grenoble, France.
Max Delbrück Center for Molecular Medicine, D-13125 Berlin, Germany.
Institute of Physiological Chemistry and the Focus Program Translational Neuroscience, University Medical Center of the Johannes Gutenberg University Mainz, D-55128 Mainz, Germany, and Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, D-80336 Munich, Germany.


Vital organs such as the pancreas and the brain lack the capacity for effective regeneration. To overcome this limitation, an emerging strategy consists of converting resident tissue-specific cells into the cell types that are lost due to disease by a process called in vivo lineage reprogramming. Here we discuss recent breakthroughs in regenerating pancreatic β-cells and neurons from various cell types, and highlight fundamental challenges that need to be overcome for the translation of in vivo lineage reprogramming into therapy.

[Indexed for MEDLINE]

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