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Nat Cell Biol. 2015 Mar;17(3):204-11. doi: 10.1038/ncb3108.

In vivo reprogramming for tissue repair.

Author information

1
INSERM U836, F-38000 Grenoble, France and Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F-38000 Grenoble, France.
2
Max Delbrück Center for Molecular Medicine, D-13125 Berlin, Germany.
3
Institute of Physiological Chemistry and the Focus Program Translational Neuroscience, University Medical Center of the Johannes Gutenberg University Mainz, D-55128 Mainz, Germany, and Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, D-80336 Munich, Germany.

Abstract

Vital organs such as the pancreas and the brain lack the capacity for effective regeneration. To overcome this limitation, an emerging strategy consists of converting resident tissue-specific cells into the cell types that are lost due to disease by a process called in vivo lineage reprogramming. Here we discuss recent breakthroughs in regenerating pancreatic β-cells and neurons from various cell types, and highlight fundamental challenges that need to be overcome for the translation of in vivo lineage reprogramming into therapy.

PMID:
25720960
DOI:
10.1038/ncb3108
[Indexed for MEDLINE]

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