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Genes Dev. 2015 Feb 15;29(4):337-49. doi: 10.1101/gad.256495.114.

Nuclear pore proteins and the control of genome functions.

Author information

1
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA.
2
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA hetzer@salk.edu.

Abstract

Nuclear pore complexes (NPCs) are composed of several copies of ∼30 different proteins called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the nucleocytoplasmic trafficking of macromolecules. Beyond this vital role, NPC components influence genome functions in a transport-independent manner. Nups play an evolutionarily conserved role in gene expression regulation that, in metazoans, extends into the nuclear interior. Additionally, in proliferative cells, Nups play a crucial role in genome integrity maintenance and mitotic progression. Here we discuss genome-related functions of Nups and their impact on essential DNA metabolism processes such as transcription, chromosome duplication, and segregation.

KEYWORDS:

DNA damage; mitosis; nuclear envelope; nuclear genome; nuclear pore complex; nucleoporin; transcription control

PMID:
25691464
PMCID:
PMC4335290
DOI:
10.1101/gad.256495.114
[Indexed for MEDLINE]
Free PMC Article

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