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Cancer Res. 2015 Mar 1;75(5):792-7. doi: 10.1158/0008-5472.CAN-14-2750. Epub 2015 Feb 13.

Fearful symmetry: subversion of asymmetric division in cancer development and progression.

Author information

1
Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, California. Sanford Consortium for Regenerative Medicine, La Jolla, California. Moores Cancer Center, University of California San Diego School of Medicine, La Jolla, California.
2
Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, California. Sanford Consortium for Regenerative Medicine, La Jolla, California. Moores Cancer Center, University of California San Diego School of Medicine, La Jolla, California. treya@ucsd.edu.

Abstract

Asymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants. While asymmetric division is critically important in generating diversity during development, its dysregulation can also promote oncogenesis. In particular, signals that shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression. Here, we discuss the studies that have provided increasing support for this idea. Beginning with original work carried out in Drosophila, we trace more recent work in mammalian systems that suggest that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers.

PMID:
25681272
PMCID:
PMC4784538
DOI:
10.1158/0008-5472.CAN-14-2750
[Indexed for MEDLINE]
Free PMC Article

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