Format

Send to

Choose Destination
Biochim Biophys Acta. 2015 Jun;1850(6):1188-96. doi: 10.1016/j.bbagen.2015.02.001. Epub 2015 Feb 7.

Turtle anoxia tolerance: Biochemistry and gene regulation.

Author information

1
Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada; Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada. Electronic address: krivoruchko@gmail.com.
2
Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada; Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada.

Abstract

BACKGROUND:

While oxygen limitation can be extremely damaging for many animals, some vertebrates have perfected anaerobic survival. Freshwater turtles belonging to the Trachemys and Chrysemys genera, for example, can survive many weeks without oxygen, and as such are commonly used as model animals for vertebrate anoxia tolerance.

SCOPE OF REVIEW:

In the present review we discuss the recent advances made in understanding the biochemical and molecular nature of natural anoxia tolerance of freshwater turtles.

MAJOR CONCLUSIONS:

Research in recent years has shown that activation of several important pathways occurs in response to anoxia in turtles, including those that function in the stress response, cell cycle arrest, inhibition of gene expression and metabolism. These likely contribute to anoxia tolerance in turtle tissues by minimizing cell damage in response to anoxia, as well as facilitating metabolic rate depression.

GENERAL SIGNIFICANCE:

The research discussed in the present review contributes to the understanding of how freshwater turtles can survive without oxygen for prolonged periods of time. This could also improve understanding of the molecular nature of hypoxic/ischemic injuries in mammalian tissues and suggest potential ways to avoid these.

KEYWORDS:

FoxO; HDAC; Heat shock response; NF-kappaB; Unfolded protein response; p53

PMID:
25662819
DOI:
10.1016/j.bbagen.2015.02.001
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center