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Resuscitation. 2015 Mar;88:81-5. doi: 10.1016/j.resuscitation.2014.12.025. Epub 2015 Jan 8.

Fulfilling caloric demands according to indirect calorimetry may be beneficial for post cardiac arrest patients under therapeutic hypothermia.

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Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan. Electronic address:
Medical Engineering Center, Chiba University Hospital, Chiba, Japan.
Department of Clinical Nutrition, Chiba University Hospital, Chiba, Japan.
Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.



We sought to investigate the energy requirements for patients under therapeutic hypothermia, and the relationship of energy fulfillment to patient outcome.


Adult patients admitted to our ICU after successful resuscitation from cardiac arrest for post resuscitation therapeutic hypothermia from April, 2012 to March, 2014 were enrolled. Body temperature was managed using the surface cooling device (Arctic Sun(®), IMI). Calorimeter module on the ventilator (Engström carestation(®), GE) was used for indirect calorimetry. Energy expenditure (EE) and respiratory quotient (RQ) were recorded continuously, as the average of the recent 2h. Measurements were started at the hypothermic phase and continued until the rewarming was completed. Cumulative energy deficit was calculated as the sum of difference between EE and daily energy provision for the 4 days during hypothermia therapy.


Seven patients were eligible for analysis. Median EE for the hypothermic phase (day 1) was 1557.0kcald(-1). EE was elevated according with the rise in body temperature, reaching 2375kcald(-1) at normothermic phase. There was significant association between cumulative energy deficit and the length of ICU stay, among patients with good neurologic recovery (cerebral performance category (CPC): 1-3).


The EE for patients under therapeutic hypothermia was higher than expected. Meeting the energy demand may improve patient outcome, as observed in the length of ICU stay for the present study. A larger, prospective study is awaited to validate the results of our study.


Indirect calorimetry; Nutrition; Post cardiac arrest; Therapeutic hypothermia

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