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Acta Neurol Belg. 2015 Dec;115(4):657-63. doi: 10.1007/s13760-014-0422-8. Epub 2015 Jan 10.

ADHD, autism and neuroradiological complications among phenylketonuric children in Upper Egypt.

Author information

1
Department of Pediatrics, Assiut University, Asyût, 71516, Egypt. ksaad8@yahoo.com.
2
Department of Neuropsychiatry, Assiut University, Asyût, 71516, Egypt.
3
Department of Psychiatry, College of Medicine, Almajmaah University, Al Majma'ah, KSA.
4
Department of Pediatrics, Assiut University, Asyût, 71516, Egypt.
5
Department of Clinical Pathology, Assiut University, Asyût, 71516, Egypt.
6
Council for Nutritional and Environmental Medicine, Mo i Rana, Norway.
7
Department of Community Health Nursing, Assiut University, Asyût, 71516, Egypt.

Abstract

The aim of this study is to evaluate the neuropsychological status in a cohort of children with early and continuously treated phenylketonuria in Assiut, Upper Egypt. The study was implemented in seventy-eight phenylketonuria (PKU) children. Only 34 patients met the inclusion criteria. Investigated patients were evaluated according to detailed history, neurological examination, Childhood Autism Rating Scale, full scale Intelligence Quotient, attention deficit hyperactivity disorder, electroencephalography and magnetic resonance imaging (MRI). This study concluded that the prognosis for early diagnosed children with PKU treated from the first weeks of life is generally good. However, they are at increased risk for neurological complications and behavioral problems. So, neonatal screening for PKU is highly recommended in Egypt, for early detection and management. In addition, neuropsychological and MRI assessments in PKU children should be done.

KEYWORDS:

ADHD; Autism; Children; Phenylketonuria

PMID:
25576444
DOI:
10.1007/s13760-014-0422-8
[Indexed for MEDLINE]

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