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BMC Genet. 2014 Dec 10;15:134. doi: 10.1186/s12863-014-0134-3.

The TCF7L2 rs7903146 polymorphism, dietary intakes and type 2 diabetes risk in an Algerian population.

Author information

1
Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf, Oran, Algeria. djellouli.ouhaibi@gmail.com.
2
Département de Biotechnologie, Faculté des Sciences de la Nature et de la Vie, Université d'Oran, Oran, Algeria. djellouli.ouhaibi@gmail.com.
3
Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf, Oran, Algeria. sonia_mediene@yahoo.fr.
4
Département de Biotechnologie, Faculté des Sciences de la Nature et de la Vie, Université d'Oran, Oran, Algeria. sonia_mediene@yahoo.fr.
5
Département de Biotechnologie, Faculté des Sciences de la Nature et de la Vie, Université d'Oran, Oran, Algeria. lardjamhetraf.sarah@gmail.com.
6
Caisse Nationale des Assurances Sociales des Travailleurs Salariés, Clinique Spécialisée en Orthopédie et Rééducation des Victimes des Accidents de Travail, Oran, Algeria. amanim20002000@yahoo.fr.
7
Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf, Oran, Algeria. meroufeln@yahoo.fr.
8
Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf, Oran, Algeria. boulenouar.houssam@gmail.com.
9
INSERM, U744; Institut Pasteur de Lille, Université de Lille, 1 rue du Pr. Calmette, BP 245, F-59019, Lille, France. xavier.hermant@pasteur-lille.fr.
10
Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf, Oran, Algeria. nmehtar2002@yahoo.fr.
11
INSERM, U744; Institut Pasteur de Lille, Université de Lille, 1 rue du Pr. Calmette, BP 245, F-59019, Lille, France. philippe.amouyel@pasteur-lille.fr.
12
Faculté de Médecine, Université Djillali Liabes de Sidi Bel Abbès, Sidi Bel Abbès, Algeria. leilahouti@yahoo.fr.
13
Laboratoire des Systèmes d'Information en Santé, Université d'Oran, Oran, Algeria. leilahouti@yahoo.fr.
14
INSERM, U744; Institut Pasteur de Lille, Université de Lille, 1 rue du Pr. Calmette, BP 245, F-59019, Lille, France. louisa.goumidi@pasteur-lille.fr.
15
INSERM, U744; Institut Pasteur de Lille, Université de Lille, 1 rue du Pr. Calmette, BP 245, F-59019, Lille, France. aline.meirhaeghe@pasteur-lille.fr.

Abstract

BACKGROUND:

The transcription factor 7-like 2 (TCF7L2) gene is the most significant genetic risk factor for type 2 diabetes (T2D). Association analyses were performed on participants (n = 751, aged between 30 and 64) in the ISOR population-based study in the city of Oran. Dietary intakes were estimated using a weekly food frequency questionnaire.

RESULTS:

The T allele of the rs7903146 single nucleotide polymorphism (SNP) was associated with lower body weight (p = 0.02), lower BMI (p = 0.009), lower waist circumference (p = 0.01) and a lower waist-to-hip ratio (p = 0.02). The T allele was associated with a significantly higher risk of T2D (odds ratio (OR) (95% confidence interval) = 1.55 (1.09-2.20), p = 0.01) and this association was independent of BMI. When considering the T2D risk, there were nominal interactions between the rs7903146 SNP and dessert (p = 0.05) and milk intakes (p = 0.01). The T2D risk was greater in T allele carriers with high dessert and milk intakes (OR = 2.61 (1.51-4.52), p = 0.0006, and 2.46 (1.47-4.12), p = 0.0006, respectively). In subjects with a high dessert intake, the T allele was also associated with higher fasting plasma glucose concentrations (4.89 ± 0.46 mmol/L in TT subjects, 4.72 ± 0.48 mmol/L in CT subjects and 4.78 ± 0.51 mmol/L in CC subjects; p = 0.03).

CONCLUSIONS:

The T allele of the rs7903146 SNP is associated with a significantly higher risk of T2D in an Algerian population. This association was further strengthened by a high dessert intake, suggesting that gene-diet interactions increase the T2D risk.

PMID:
25491720
PMCID:
PMC4266211
DOI:
10.1186/s12863-014-0134-3
[Indexed for MEDLINE]
Free PMC Article

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