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Cancer Cell. 2014 Dec 8;26(6):940-940.e1. doi: 10.1016/j.ccell.2014.11.015.

SnapShot: Medulloblastoma.

Author information

1
Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.
2
Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada.
3
Departments of Pathology, Ophthalmology, and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Medulloblastoma (MB) is the most common malignant brain tumor in children, where one-third of patients succumb to their disease. This SnapShot describes the classification of MB subgroups, historically by histopathology and currently based on genomic information. Genomics-based classification has identified four major subgroups and provides greater opportunity for developing targeted therapies more successful than current conventional therapy.

PMID:
25490452
PMCID:
PMC4324613
DOI:
10.1016/j.ccell.2014.11.015
[Indexed for MEDLINE]
Free PMC Article

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