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Curr Opin Plant Biol. 2015 Feb;23:98-108. doi: 10.1016/j.pbi.2014.11.008. Epub 2014 Nov 26.

From phenotypes to causal sequences: using genome wide association studies to dissect the sequence basis for variation of plant development.

Author information

1
Gregor Mendel Institute (GMI), Austrian Academy of Sciences, Vienna Biocenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria.
2
Gregor Mendel Institute (GMI), Austrian Academy of Sciences, Vienna Biocenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria. Electronic address: wolfgang.busch@gmi.oeaw.ac.at.

Abstract

Tremendous natural variation of growth and development exists within species. Uncovering the molecular mechanisms that tune growth and development promises to shed light on a broad set of biological issues including genotype to phenotype relations, regulatory mechanisms of biological processes and evolutionary questions. Recent progress in sequencing and data processing capabilities has enabled Genome Wide Association Studies (GWASs) to identify DNA sequence polymorphisms that underlie the variation of biological traits. In the last years, GWASs have proven powerful in revealing the complex genetic bases of many phenotypes in various plant species. Here we highlight successful recent GWASs that uncovered mechanistic and sequence bases of trait variation related to plant growth and development and discuss important considerations for conducting successful GWASs.

PMID:
25449733
DOI:
10.1016/j.pbi.2014.11.008
[Indexed for MEDLINE]

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