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Addict Biol. 2015 Sep;20(5):872-6. doi: 10.1111/adb.12205. Epub 2014 Dec 1.

Recent updates on incubation of drug craving: a mini-review.

Author information

1
Behavioral Neuroscience Research Branch, Intramural Research Program, NIDA, NIH, DHHS, Baltimore, MD, USA.
2
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia.

Abstract

Cue-induced drug craving progressively increases after prolonged withdrawal from drug self-administration in laboratory animals, a behavioral phenomenon termed 'incubation of drug craving.' Studies over the years have revealed several important neural mechanisms contributing to incubation of drug craving. In this mini-review, we first discuss three excellent Addiction Biology publications on incubation of drug craving in both human and laboratory animals. We then review several key publications from the past year on behavioral and mechanistic findings related to incubation of drug craving.

KEYWORDS:

Addiction; cocaine; dopamine; glutamate; incubation; relapse

PMID:
25440081
PMCID:
PMC4451451
DOI:
10.1111/adb.12205
[Indexed for MEDLINE]
Free PMC Article

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