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Adv Mater. 2015 Jan 14;27(2):215-22. doi: 10.1002/adma.201404256. Epub 2014 Nov 25.

Large-pore ultrasmall mesoporous organosilica nanoparticles: micelle/precursor co-templating assembly and nuclear-targeted gene delivery.

Author information

1
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai, 200050, PR China.

Abstract

A novel micelle/precursor co-templating assembly strategy is successfully developed to synthesize large-pore ultrasmall mesoporous organosilica nanoparticles (MONs). Furthermore, elaborately designed MONs with a cell-penetrating peptide (TAT) (MONs-PTAT) are constructed for highly efficient intranuclear gene delivery. They exhibit a high loading capacity, improved protection for the loaded gene, and enhanced transfection efficiencies of EGFP plasmid (pEGFP).

KEYWORDS:

gene delivery; large mesopores; mesoporous organosilicas; nuclear-targeted

PMID:
25423915
DOI:
10.1002/adma.201404256
[Indexed for MEDLINE]

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