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J Thorac Oncol. 2014 Sep;9(9 Suppl 2):S81-7. doi: 10.1097/JTO.0000000000000291.

The IASLC/ITMIG Thymic Epithelial Tumors Staging Project: proposals for the N and M components for the forthcoming (8th) edition of the TNM classification of malignant tumors.

Collaborators (196)

Goldstraw P, Rami-Porta R, Asamura H, Ball D, MacCallum P, Beer D, Beyruti R, Bolejack V, Chansky K, Crowley J, Detterbeck F, Eberhardt WE, Edwards J, Galateau-Sallé F, Giroux D, Gleeson F, Groome P, Huang J, Kennedy C, Kim J, Kim YT, Kingsbury L, Kondo H, Krasnik M, Kubota K, Lerut A, Lyons G, Marino M, Marom EM, van Meerbeeck J, Mitchell A, Nakano T, Nicholson AG, Brompton R, Nowak A, Peake M, Rice T, Rosenzweig K, Ruffini E, Rusch V, Saijo N, Van Schil P, Sculier JP, Shemanski L, Stratton K, Suzuki K, Tachimori Y, Thomas CF Jr, Travis W, Tsao MS, Turrisi A, Vansteenkiste J, Watanabe H, Wu YL, Falkson C, Filosso PL, Giaccone G, Kondo K, Lucchi M, Okumura M, Baas P, Erasmus J, Hasegawa S, Inai K, Kernstine K, Kindler H, Krug L, Nackaerts K, Pass H, Rice D, Blackstone E, Call Caja S, Ahmad U, Detterbeck F, Girard N, Haam SJ, Bae MK, Gomez DR, Marom EM, Van Schil P, Ströbel P, Marx A, Saita S, Wakelee H, Bertolaccini L, Vallieres E, Scott W, Su S, Park B, Marks J, Khella S, Shen R, Rosenberg M, Rosenberg M, Tomulescu V, Huang J, Foroulis C, Lang-Lazdunski L, Billè A, Maessen JG, Keijzers M, van Veer H, Wright C, Marino M, Facciolo F, Palmieri G, Buonerba C, Ferguson M, Marulli G, Lucchi M, Loehrer P, Kalkat M, Rohrberg K, Daugaard G, Toker A, Erus S, Kimmich M, Brunelli A, Refai M, Nicholson A, Lim E, Park IK, Wagner J, Tieu B, Fang W, Zhang J, Yu Z, Han Y, Li Y, Chen K, Chen G, Okumura M, Fujii Y, Asamura H, Nagai K, Nakajima J, Ikeda N, Haraguchi S, Onuki T, Suzuki K, Yoshino I, Tsuchida M, Takahashi S, Yokoi K, Hanyuda M, Niwa H, Date H, Maniwa Y, Miyoshi S, Kondo K, Iwasaki A, Okamoto T, Nagayasu T, Tanaka F, Suzuki M, Yoshida K, Okuma Y, Horio H, Matsumura A, Higashiyama M, Suehisa H, Onuki T, Sano Y, Kondo K, Al Kattan K, Cerfolio R, Gebitekin C, de Antonio D, Kernstine KH, Altorki N, Novoa N, Ruffini E, Filosso PL, Saita S, Scarci M, Voltolini L, Weder W, Zurek W, Arame A, Casadio C, Carbognani P, Donati G, Keshavjee S, Klepetko W, Moser B, Lequaglie C, Liberman M, Mancuso M, Nosotti M, Spaggiari L, Thomas PA, Rendina E, Venuta F, Anile M, Schützner J, Rocco G.

Author information

1
*Thoracic Surgery, University of Tokushima, Tokushima, Japan; †Thoracic Surgery, Antwerp University Hospital, Antwerp, Belgium; ‡Thoracic Surgery, Yale University, New Haven, CT; §Thoracic Surgery, Osaka University, Osaka, Japan; ‖Biostatistics, Cancer Research And Biostatistics, Seattle, WA; ¶Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan; #Radiation Oncology, Queen's University, Ontario, Canada; **Thoracic Surgery, University of Torino, Torino, Italy; ††Medical Oncology, Georgetown University, Washington, DC; ‡‡Thoracic Surgery, Sloan Kettering Cancer Center, New York, NY; §§Thoracic Surgery, Samsung Medical Center, Seoul, South Korea; ‖‖Thoracic Surgery, University of Pisa, Pisa, Italy; ¶¶Pathology, Regina Elena National Cancer Institute, Rome, Italy; ##Radiology, MD Anderson Cancer Center, Houston, TX; ***Pathology, Royal Brompton Hospital, London, UK.

Abstract

Stage classification is an important underpinning of management of patients with cancer, and rests on a combination of three components: T for tumor extent, N for nodal involvement, and M for more distant metastases. This article details an initiative to develop proposals for the first official stage classification system for thymic malignancies for the 8th edition of the stage classification manuals. Specifically, the results of analysis of a large database and the considerations leading to the proposed N and M components are described. Nodal involvement is divided into an anterior (N1) and a deep (N2) category. Metastases can involve pleural or pericardial nodules (M1a) or intraparenchymal pulmonary nodules or metastases to distant sites (M1b).

PMID:
25396316
DOI:
10.1097/JTO.0000000000000291
[Indexed for MEDLINE]
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