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Elife. 2014 Oct 28;3. doi: 10.7554/eLife.04909.

Closing in on a mechanism for activation.

Author information

1
Stevan R Hubbard is in the Kimmel Center for Biology and Medicine at the Skirball Institute and the Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, United States stevan.hubbard@med.nyu.edu.
2
W Todd Miller is in the Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States todd.miller@stonybrook.edu.

Abstract

When insulin-like growth factor-1 (IGF1) binds to its receptor, a physical constraint is released that allows the two transmembrane helices to come together to facilitate activation of the receptor.

KEYWORDS:

FRET; IGF1 receptor; biochemistry; biophysics; human; kinetics; mechanism; structural biology

PMID:
25350976
PMCID:
PMC4210822
DOI:
10.7554/eLife.04909
[Indexed for MEDLINE]
Free PMC Article

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