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Exp Dermatol. 2015 Jan;24(1):55-7. doi: 10.1111/exd.12568. Epub 2014 Nov 20.

Calmodulin 4 is dispensable for epidermal barrier formation and wound healing in mice.

Author information

1
Laboratory of Skin Biology, National Institute for Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA.

Abstract

Calcium-mediated signals play important roles in epidermal barrier formation, skin homoeostasis and wound repair. Calmodulin 4 (Calm4) is a small, Ca2+ -binding protein with strong expression in suprabasal keratinocytes. In mice, Calm4 first appears in the skin at the time of barrier formation, and its expression increases in response to epidermal barrier challenges. In this study, we report the generation of Calm4 knockout mice and provide evidence that Calm4 is dispensable for epidermal barrier formation, maintenance and repair.

KEYWORDS:

calcium-binding protein; epidermis; skin barrier; wound repair

PMID:
25316000
PMCID:
PMC4289410
DOI:
10.1111/exd.12568
[Indexed for MEDLINE]
Free PMC Article

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