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Eur J Cancer Care (Engl). 2015 Sep;24(5):605-17. doi: 10.1111/ecc.12246. Epub 2014 Oct 8.

Treatment-related problems experienced by cancer patients undergoing chemotherapy: a scoping review.

Author information

1
Faculty of Health Sciences, Highfield, University of Southampton, Southampton, UK.
2
Faculty of Health Science, Southampton General Hospital, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, UK.
3
Florence Nightingale School of Nursing & Midwifery King's College London, London, UK.
4
Centre for Innovation and Leadership in Health Sciences, Faculty of Health Sciences, University of Southampton, Southampton, UK.
5
University Hospital Southampton, Southampton, UK.
6
Centre for Innovation and Leadership in Health Sciences, Faculty of Health Sciences, Highfield, University of Southampton, Southampton, UK.

Abstract

Cancer patients undergoing chemotherapy experience a range of treatment-related problems, and variations in prevalence exist between treatment centres. A scoping review was undertaken to map reported rates of problem prevalence in the literature. This will inform development of a patient-reported outcome measure (PROM) to monitor prevalence and severity of problems over time and assist service providers optimise supportive care provision. Two databases (Embase and Medline) were searched from 2002 to 2013. Fifty one published papers and conference abstracts reporting problem prevalence rates were identified. The papers reported 98 different problems, from which a typology of 27 problem domains was developed, including both physical symptoms and psychosocial issues. The problem domains most often studied were nausea, vomiting and fatigue. This review reflects the chemotherapy-associated problems to which researchers attach the most importance. The range in reported prevalence across studies was very broad (e.g. nausea: 9-74%), with even less frequently studied problems showing high prevalence in some studies (e.g. gynaecological problems: up to 94%). The wide variation in prevalence and range of problems experienced raises challenges for PROM development. Patients should therefore be involved in consensus exercises to assist selection of items to ensure any instrument is complete and robust.

KEYWORDS:

cancer; chemotherapy; quality of life; supportive care; symptoms

PMID:
25296389
DOI:
10.1111/ecc.12246
[Indexed for MEDLINE]

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