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Cancer Epidemiol. 2014 Dec;38(6):700-7. doi: 10.1016/j.canep.2014.09.005. Epub 2014 Sep 30.

Sexual partners, sexually transmitted infections, and prostate cancer risk.

Author information

1
INRS-Institut Armand-Frappier, Université du Québec, Laval, QC, Canada.
2
INRS-Institut Armand-Frappier, Université du Québec, Laval, QC, Canada; Department of Social and Preventive Medicine, University of Montreal, Montréal, QC, Canada; University of Montreal Hospital Research Centre (CRCHUM), Montréal, QC, Canada.
3
INRS-Institut Armand-Frappier, Université du Québec, Laval, QC, Canada; Department of Social and Preventive Medicine, University of Montreal, Montréal, QC, Canada; University of Montreal Hospital Research Centre (CRCHUM), Montréal, QC, Canada. Electronic address: marie-elise.parent@iaf.inrs.ca.

Abstract

BACKGROUND:

The etiology of prostate cancer (PCa) is poorly understood. Sexual activity and sexually transmitted infections (STIs) are among factors under scrutiny, with controversial findings to date.

METHODS:

We examined the association between the number and gender of sexual partners, STIs and PCa risk in the context of PROtEuS, a population-based case-control study set amongst the mainly French-speaking population in Montreal, Canada. The study included 1590 histologically-confirmed PCa cases diagnosed in a Montreal French hospital between 2005 and 2009, and 1618 population controls ascertained from the French electoral list, Montreal residents, frequency-matched to cases by age. In-person interviews elicited information on sociodemographic, lifestyle and environmental factors. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) between sexually related factors and PCa risk, adjusting for age, ancestry, family history of PCa, and PCa screening history.

RESULTS:

Subjects with more than 20 sexual partners in their lifetime had a decreased risk of PCa (OR 0.78, 95% CI 0.61-1.00) as did subjects who specifically had more than 20 female sexual partners (OR 0.72, 95% CI 0.56-0.94). By contrast, having had several male sexual partners appeared to confer some excess in risk of PCa. No association emerged for history of STIs and PCa but STIs prevalence was low.

CONCLUSION:

Our findings are in support of a role for the number of sexual partners in PCa development. The gender of sexual partners should be taken into account in future studies investigating this association.

KEYWORDS:

Prostate cancer; Sexual activity; Sexual orientation; Sexual partners; Sexually transmitted infections

PMID:
25277695
DOI:
10.1016/j.canep.2014.09.005
[Indexed for MEDLINE]

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