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J Comp Eff Res. 2014 Jul;3(4):359-69. doi: 10.2217/cer.14.25.

Implications of different laboratory-based incident diabetic kidney disease definitions on comparative effectiveness studies.

Author information

1
Institute for Health Research, Kaiser Permanente Colorado, Denver, CO 80231, USA.

Abstract

BACKGROUND:

Comparative effectiveness studies using electronic health records (EHRs) often define chronic kidney disease (CKD) outcomes using laboratory-based definitions. Recommendations for defining CKD require multiple longitudinal measurements. The implications of applying these definitions to EHR data are poorly understood.

METHODS:

Using a cohort of 36,025 individuals with diabetes from three health systems who initiated a new glucose-lowering medication, we compared concordance and CKD incidence rates and rate ratios for glucose-lowering medication classes for laboratory-based CKD definitions requiring one versus multiple abnormal tests.

RESULTS & CONCLUSION:

CKD incidence rates differed more than twofold based on the definition. Reassuring for CER, incidence rate ratios for glucose-lowering medication classes on risk of developing CKD were relatively unaffected by CKD definition.

KEYWORDS:

chronic kidney disease; comparative effectiveness research; diabetes mellitus; electronic health records

PMID:
25275233
DOI:
10.2217/cer.14.25
[Indexed for MEDLINE]

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