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Dev Cell. 2014 Sep 29;30(6):641-2. doi: 10.1016/j.devcel.2014.09.003.

Worming toward transdifferentiation, one (Epigenetic) step at a time.

Author information

1
Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA.
2
Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: belmonte@salk.edu.

Abstract

Manipulation of cellular identity in the laboratory is generally inefficient due to stochastic events, including epigenomic alterations. Recently in Science, Zuryn et al. (2014) demonstrate that the efficiency of a naturally occurring transdifferentiation event in Caenorhabditis elegans is ensured through stepwise epigenetic modifications during specific phases of lineage conversion.

PMID:
25268170
DOI:
10.1016/j.devcel.2014.09.003
[Indexed for MEDLINE]
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