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Cell. 2014 Sep 25;159(1):11-12. doi: 10.1016/j.cell.2014.09.013.

ALT telomeres borrow from meiosis to get moving.

Author information

1
The Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
2
The Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: karlseder@salk.edu.

Abstract

Telomere clustering is required for the homologous recombination events that maintain chromosome ends in cells relying on alternative lengthening of telomeres (ALT). New data demonstrate that damage signaling at telomeres, a likely step in activating maintenance mechanisms, induces directional movement and synapsis driven by the machinery responsible for recombination in meiosis.

PMID:
25259914
PMCID:
PMC4389894
DOI:
10.1016/j.cell.2014.09.013
[Indexed for MEDLINE]
Free PMC Article

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