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F1000Res. 2014 Jul 1;3:153. doi: 10.12688/f1000research.4572.1. eCollection 2014.

GeneMANIA: Fast gene network construction and function prediction for Cytoscape.

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1
Departments of Molecular Genetics and Computer Science, The Donnelly Centre, University of Toronto, Toronto, ON, M5S 3E1, Canada.

Abstract

The GeneMANIA Cytoscape app enables users to construct a composite gene-gene functional interaction network from a gene list. The resulting network includes the genes most related to the original list, and functional annotations from Gene Ontology. The edges are annotated with details about the publication or data source the interactions were derived from. The app leverages GeneMANIA's database of 1800+ networks, containing over 500 million interactions spanning 8 organisms: A. thaliana, C. elegans, D. melanogaster, D. rerio, H. sapiens, M. musculus, R. norvegicus, and S. cerevisiae. Users may also import their own organisms, networks, and expression profiles. The app is compatible with Cytoscape versions 2 and 3.

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