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Br J Nutr. 2014 Nov 14;112(9):1447-58. doi: 10.1017/S0007114514002396. Epub 2014 Sep 19.

Finger millet bran supplementation alleviates obesity-induced oxidative stress, inflammation and gut microbial derangements in high-fat diet-fed mice.

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National Agri-Food Biotechnology Institute (NABI),C-127, Industrial Area, Phase 8, SAS Nagar,160 071,Punjab,India.
National Institute of Pharmaceutical Education and Research (NIPER),SAS Nagar,Punjab,India.
Division of Biomedical Sciences, School of Biosciences and Technology, VIT University,Vellore,Tamil Nadu,India.
Department of Millets,Tamil Nadu Agricultural University,Coimbatore,Tamil Nadu,India.
Department of Biotechnology,Indian Institute of Technology Madras,Chennai,Tamil Nadu,India.
Department of Biochemistry,Panjab University,Chandigarh,India.


Several epidemiological studies have shown that the consumption of finger millet (FM) alleviates diabetes-related complications. In the present study, the effect of finger millet whole grain (FM-WG) and bran (FM-BR) supplementation was evaluated in high-fat diet-fed LACA mice for 12 weeks. Mice were divided into four groups: control group fed a normal diet (10 % fat as energy); a group fed a high-fat diet; a group fed the same high-fat diet supplemented with FM-BR; a group fed the same high-fat diet supplemented with FM-WG. The inclusion of FM-BR at 10 % (w/w) in a high-fat diet had more beneficial effects than that of FM-WG. FM-BR supplementation prevented body weight gain, improved lipid profile and anti-inflammatory status, alleviated oxidative stress, regulated the expression levels of several obesity-related genes, increased the abundance of beneficial gut bacteria (Lactobacillus, Bifidobacteria and Roseburia) and suppressed the abundance of Enterobacter in caecal contents (P≤ 0·05). In conclusion, FM-BR supplementation could be an effective strategy for preventing high-fat diet-induced changes and developing FM-BR-enriched functional foods.

[Indexed for MEDLINE]

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