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J Infect Dis. 2015 May 15;211(10):1560-5. doi: 10.1093/infdis/jiu524. Epub 2014 Sep 17.

Human polyomavirus 7-associated pruritic rash and viremia in transplant recipients.

Author information

1
Department of Dermatology.
2
Cancer Virology Program, Cancer Institute, University of Pittsburgh, Pennsylvania.
3
Division of Pulmonary, Allergy, and Critical Care.
4
Department of Medicine.
5
Department of Pathology, School of Medicine.
6
Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

Abstract

Human polyomavirus 7 (HPyV7) is one of 11 HPyVs recently discovered through genomic sequencing technologies. Two lung transplant recipients receiving immunosuppressive therapy developed pruritic, brown plaques on the trunk and extremities showing a distinctive epidermal hyperplasia with virus-laden keratinocytes containing densely packed 36-45-nm icosahedral capsids. Rolling circle amplification and gradient centrifugation testing were positive for encapsidated HPyV7 DNA in skin and peripheral blood specimens from both patients, and HPyV7 early and capsid proteins were abundantly expressed in affected tissues. We describe for the first time that HPyV7 is associated with novel pathogenicity in some immunosuppressed individuals.

KEYWORDS:

HPyV7; immunosuppression; polyomavirus; skin viral infection; transplantation-associated disease

PMID:
25231015
PMCID:
PMC4425822
DOI:
10.1093/infdis/jiu524
[Indexed for MEDLINE]
Free PMC Article

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