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Alzheimers Dement. 2015 Feb;11(2):151-60.e5. doi: 10.1016/j.jalz.2013.12.019. Epub 2014 Sep 13.

Harmonized benchmark labels of the hippocampus on magnetic resonance: the EADC-ADNI project.

Author information

1
LENITEM (Laboratory of Epidemiology, Neuroimaging and Telemedicine), IRCCS-Centro S. Giovanni di Dio-Fatebenefratelli Brescia, Brescia, Italy; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
2
LENITEM (Laboratory of Epidemiology, Neuroimaging and Telemedicine), IRCCS-Centro S. Giovanni di Dio-Fatebenefratelli Brescia, Brescia, Italy.
3
Department of Radiology, Université Laval and Centre de Recherche de l'Institut universitaire de santé mentale de Québec, Quebec City, Canada.
4
Mary S. Easton Center for Alzheimer's Disease Research and Laboratory of NeuroImaging, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
5
Department of Diagnostic Radiology, Mayo Clinic and Foundation, Rochester, MN, USA.
6
Klinik für Psychiatrie und Psychotherapie, Johannes Gutenberg-Universität Mainz, Mainz, Germany.
7
IRCCS-Centro S. Giovanni di Dio-Fatebenefratelli Brescia, Brescia, Italy.
8
SeSMIT (Service for Medical Statistics and Information Technology), AFaR (Fatebenefratelli Association for Research), Fatebenefratelli Hospital, Rome, Italy; Unit of Clinical and Molecular Epidemiology, IRCCS "San Raffaele Pisana," Rome, Italy.
9
LENITEM (Laboratory of Epidemiology, Neuroimaging and Telemedicine), IRCCS-Centro S. Giovanni di Dio-Fatebenefratelli Brescia, Brescia, Italy; Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland. Electronic address: gfrisoni@fatebenefratelli.it.

Abstract

BACKGROUND:

A globally harmonized protocol (HarP) for manual hippocampal segmentation based on magnetic resonance has been recently developed by a task force from European Alzheimer's Disease Consortium (EADC) and Alzheimer's Disease Neuroimaging Initiative (ADNI). Our aim was to produce benchmark labels based on the HarP for manual segmentation.

METHODS:

Five experts of manual hippocampal segmentation underwent specific training on the HarP and segmented 40 right and left hippocampi from 10 ADNI subjects on both 1.5 T and 3 T scans. An independent expert visually checked segmentations for compliance with the HarP. Descriptive measures of agreement between tracers were intraclass correlation coefficients (ICCs) of crude volumes and similarity coefficients of three-dimensional volumes.

RESULTS:

Two hundred labels have been provided for the 20 magnetic resonance images. Intra- and interrater ICCs were >0.94, and mean similarity coefficients were 1.5 T, 0.73 (95% confidence interval [CI], 0.71-0.75); 3 T, 0.75 (95% CI, 0.74-0.76).

CONCLUSION:

Certified benchmark labels have been produced based on the HarP to be used for tracers' training and qualification.

KEYWORDS:

ADNI; Alzheimer's disease; Anatomic landmark; Harmonization; Harmonized protocol; Hippocampal atrophy; Hippocampal volume; Hippocampus; MRI; Manual tracing; Medial temporal lobes; Neuroimaging; Standard operating procedures

PMID:
25223727
DOI:
10.1016/j.jalz.2013.12.019
[Indexed for MEDLINE]

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