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Cereb Cortex. 2016 Feb;26(2):467-76. doi: 10.1093/cercor/bhu213. Epub 2014 Sep 12.

Midcingulate Motor Map and Feedback Detection: Converging Data from Humans and Monkeys.

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Institut National de la Santé et de la Recherche Médicale U846, Stem Cell and Brain Research Institute, 69500 Bron, France Université de Lyon, Lyon 1, Unité Mixte de Recherche S-846, 69003 Lyon, France.
Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A2B4.


The functional and anatomical organization of the cingulate cortex across primate species is the subject of considerable and often confusing debate. The functions attributed to the midcingulate cortex (MCC) embrace, among others, feedback processing, pain, salience, action-reward association, premotor functions, and conflict monitoring. This multiplicity of functional concepts suggests either unresolved separation of functional contributions or integration and convergence. We here provide evidence from recent experiments in humans and from a meta-analysis of monkey data that MCC feedback-related activity is generated in the rostral cingulate premotor area by specific body maps directly related to the modality of feedback. As such, we argue for an embodied mechanism for adaptation and exploration in MCC. We propose arguments and precise tools to resolve the origins of performance monitoring signals in the medial frontal cortex, and to progress on issues regarding homology between human and nonhuman primate cingulate cortex.


decision; learning; prefrontal; primate; reward

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