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Exp Cell Res. 2014 Dec 10;329(2):234-8. doi: 10.1016/j.yexcr.2014.08.033. Epub 2014 Sep 3.

microRNAs in hematopoiesis.

Author information

1
Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands. Electronic address: s.s.lazare@umcg.nl.
2
Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands.

Abstract

miRNAs have been implicated in all stages of hematopoiesis including maintenance of self-renewal of hematopoietic stem cells (HSCs) and differentiation into mature blood cells. Regulation by miRNAs is markedly intertwined with transcription factors. In this review, we highlight miRNAs shown to be important for HSC maintenance and lineage differentiation with focus on their interaction with transcription factors. We also pay attention to the diverse modes of miRNA regulation.

KEYWORDS:

Hematopoiesis; Lineage commitment; Transcription factors; microRNA

PMID:
25192911
DOI:
10.1016/j.yexcr.2014.08.033
[Indexed for MEDLINE]

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