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Genes Dev. 2014 Sep 1;28(17):1857-8. doi: 10.1101/gad.250316.114.

Modern genome editing meets telomeres: the many functions of TPP1.

Author information

1
The Salk Institute, La Jolla, California 92037, USA karlseder@salk.edu.

Abstract

The telomeric complex has been analyzed in detail for its role in regulating telomere protection and telomere length. Now, modern genome-editing techniques in human embryonic stem cells reveal TPP1 as the essential recruitment factor for telomerase, with additional functions in telomerase activation and definition of telomere length homeostasis.

KEYWORDS:

embryonic stem cells; human genome engineering; shelterin; telomerase; telomere maintenance

PMID:
25184673
PMCID:
PMC4197952
DOI:
10.1101/gad.250316.114
[Indexed for MEDLINE]
Free PMC Article

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