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Nat Genet. 2014 Sep;46(9):929-31. doi: 10.1038/ng.3074.

RNA switch at enhancers.

Author information

1
Department of Bioengineering at Stanford University, Stanford, California, USA.
2
Program in Epithelial Biology and the Howard Hughes Medical Institute at Stanford University, Stanford, California, USA.

Abstract

Polycomb/Trithorax response elements (PRE/TREs) are genetic elements that can stably silence or activate genes. A new study describes how long noncoding RNAs (lncRNAs) transcribed from opposite strands of the Drosophila melanogaster vestigial PRE/TRE throw the switch between these two opposing epigenetic states.

PMID:
25162802
DOI:
10.1038/ng.3074
[Indexed for MEDLINE]

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