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Drug Discov Today. 2014 Nov;19(11):1696-1698. doi: 10.1016/j.drudis.2014.08.003. Epub 2014 Aug 19.

Expanding the scope of drug repurposing in pediatrics: the Children's Pharmacy Collaborative.

Author information

1
Division of Pediatric Hematology Oncology, University of North Carolina, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA. Electronic address: jblat@med.unc.edu.
2
Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
3
Division of Pediatric Hematology Oncology, Children's Memorial Hospital, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
4
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA; Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.

Abstract

Drug repurposing is the use of 'old' drugs for new indications, avoiding the need for time- and cost-intensive toxicity studies. This approach should be particularly attractive for pediatrics, but its use in this population has been limited. One obstacle has been the lack of a comprehensive database of drugs for which there already is at least one indication in children. We describe the development of The Children's Pharmacy Collaborative, which should grow over time, serve as a resource for professionals and families, and stimulate drug-repurposing efforts for a range of pediatric disorders.

PMID:
25149597
PMCID:
PMC4578872
DOI:
10.1016/j.drudis.2014.08.003
[Indexed for MEDLINE]
Free PMC Article

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