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J Infect Dis. 2015 Feb 1;211(3):481-5. doi: 10.1093/infdis/jiu449. Epub 2014 Aug 12.

In vivo prediction of tuberculosis-associated cavity formation in rabbits.

Author information

1
Johns Hopkins Center for Tuberculosis Research.
2
Johns Hopkins Center for Tuberculosis Research Department of Medicine, Imperial College London, United Kingdom.
3
Center for Infectious Disease Imaging, Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda.
4
Johns Hopkins Center for Tuberculosis Research Center for Infection and Inflammation Imaging Research Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore.
5
Johns Hopkins Center for Tuberculosis Research Center for Infection and Inflammation Imaging Research Howard Hughes Medical Institute, Chevy Chase, Maryland.

Abstract

The presence of cavitary lesions in patients with tuberculosis poses a significant clinical concern due to the risk of infectivity and the risk of antibiotic treatment failure. We describe 2 algorithms that use noninvasive positron emission tomography (PET) and computed tomography (CT) to predict the development of cavitary lesions in rabbits. Analysis of the PET region of interest predicted cavitary disease with 100% sensitivity and 76% specificity, and analysis of the CT region of interest predicted cavitary disease with 83.3% sensitivity and 76.9% specificity. Our results show that restricting our analysis to regions with high [(18)F]-fluorodeoxyglucose uptake provided the best combination of sensitivity and specificity.

KEYWORDS:

CT; PET; [18F]-FDG; tuberculosis

PMID:
25117755
PMCID:
PMC4296171
DOI:
10.1093/infdis/jiu449
[Indexed for MEDLINE]
Free PMC Article

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