Format

Send to

Choose Destination
Eur Heart J. 2014 Nov 21;35(44):3122-33. doi: 10.1093/eurheartj/ehu293. Epub 2014 Aug 11.

Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors.

Collaborators (246)

Shimada K, Kario K, Miyashita H, Eguchi K, Kohara K, Tabara Y, Imai Y, Ito S, Hashimoto J, Uchiba K, Suzuki H, Takenaka T, Takazawa K, Kino M, Yamashina A, Tomiyama H, Dohi Y, Takase H, Tomiyama H, Yamashina A, Boutouyrie P, Laurent S, Jouven X, Empana JP, Pannier B, Thomas F, Boutouyrie P, Laurent S, Prescott E, Janner J, McEniery C, Cockroft J, Wilkinson I, Roman MJ, Devereux RB, Teal V, Townsend R, Vermeersch S, Rietzschel ER, Van Bortel L, De Buyzere ML, Segers P, Gillebert TC, Wang JG, Li Y, Wang JG, Li Y, Lazar J, Salciccioli L, Cunha P, Oliveira P, Cotter J, Vila I, Sousa N, Chirinos J, Medina-Lezama J, Weber T, Rammer M, O'Rourke MF, Bernd E, Lassnig E, Porodko M, Ammer M, Weber T, Rammer M, Wassertheurer S, Bernd E, O'Rourke MF, Adji A, Rosenkranz S, Ammer M, Weber T, Bernd E, O'Rourke MF, Ammer M, Punzengruber C, Kvas E, Dufouil C, Tzourio C, Nijpels G, Dekker JM, Ferreira I, Twisk JW, Smulders YM, Stehouwer CD, Ferreira I, van de Laar RJ, van Kallen CJ, van Greevenbroek MM, Schalkwijk CG, Stehouwer CD, Vlachopoulos C, Aznaouridis C, Terentes-Printzios D, Stefanadis C, Xaplanteris P, Schutte AE, Fourie CM, van Rooyen JM, Mahmud A, Freely J, Ghiadoni L, Stea F, Bruno RM, Cartoni G, Armenia S, Taddei S, Seidlerova J, Vanek J, Filipovsky J, Mayer O Jr, Lind L, Soveri I, Lind L, Fellström B, Zilmer M, Cavallini MC, Pini R, Di Bari M, Marchionni N, Masotti G, Schillaci G, Pucci G, Battista F, Settimi L, Crilly MA, Kumar V, Clark HJ, Scott NW, Macdonald AG, Williams DJ, Crilly MA, Williams DJ, Clark HJ, Hillis GS, Lee AJ, Crilly MA, Williams DJ, Clark HJ, de Vries A, Hillis GS, Lee AJ, Small GR, Zanchetti A, Bilo G, Taurino C, McClure JD, Schneider MP, Kawecka-Jaszcz K, Stolarz-Skrzypek K, Klima Ł, Staessen JA, Kuznetsova T, Redon J, Martinez F, Rosei EA, Melander O, Zannad F, Rossignol P, Laurent S, Collin C, Lonati L, Dominiczak AF, Adji A, O'Rourke M, Petrak O, Štrauch B, Rosa J, Widimský J Jr, Pipingas A, Pase MP, Grima NA, Stough C, Pase MP, Pipingas A, Harris E, Pipingas A, Sellick L, Macpherson H, Grima NA, Pipingas A, Pascualab JM, Rodilla E, Costa JA, Simon T, Boutouyrie P, Laurent S, Delles C, Dymott JA, Neisius U, Carty DM, Fesler P, Rosei EA, Muiesan ML, Salvettia M, Paini A, Tisler A, Zofi, Nemeth K, Marton A, El Haj Othmane T, Cseprekal O, Tisler A, Studinger P, Nik Ibrahim NN, Ghulam Rasool AH, Abdul Rahman AR, Wong AR, Protogerou AD, Papaioannou TG, Sfikakis PP, Fu Y, Hu J, Zhao L, Li N, Jiang X, Ok E, Demirci MS, Gungor O, Orlova IA, Blankova ZN, Seredenina EM, Ageev FT, Orlova IA, Barinova IV, Seredenina EM, Ageev FT, Bellien J, Iacob M, Thuillez C, Joannides, Erglis A, Mintale I, Latkovskis G, Berzina M, Zabunova M, Krallisa A, Smulyan H, Safar M, Smulyan H, Safar M, Zhadan A, Tselukyo V, Bregvadze T, Aydin A, von Kodolitsch Y.

Author information

1
Department of Pharmacology and INSERM U970, Assistance Publique Hôpitaux de Paris, Université Paris Descartes, 56 rue Leblanc, Paris 75015, France Research & Development Department, Pennine Acute Hospitals NHS Trust, Crumpsall, Manchester, UK.
2
Diabetes, Cardiovascular Medicine & Nutrition, King's College University of London & King's Health Partners, London, UK pierre.boutouyrie@egp.aphp.fr kennedy.cruickshank@kcl.ac.uk.
3
Department of Pharmacology and INSERM U970, Assistance Publique Hôpitaux de Paris, Université Paris Descartes, 56 rue Leblanc, Paris 75015, France.
4
Department of Pharmacology and INSERM U970, Assistance Publique Hôpitaux de Paris, Université Paris Descartes, 56 rue Leblanc, Paris 75015, France pierre.boutouyrie@egp.aphp.fr kennedy.cruickshank@kcl.ac.uk.

Abstract

AIMS:

Estimated central systolic blood pressure (cSBP) and amplification (Brachial SBP-cSBP) are non-invasive measures potentially prognostic of cardiovascular (CV) disease. No worldwide, multiple-device reference values are available. We aimed to establish reference values for a worldwide general population standardizing between the different available methods of measurement. How these values were significantly altered by cardiovascular risk factors (CVRFs) was then investigated.

METHODS AND RESULTS:

Existing data from population surveys and clinical trials were combined, whether published or not. Reference values of cSBP and amplification were calculated as percentiles for 'Normal' (no CVRFs) and 'Reference' (any CVRFs) populations. We included 45,436 subjects out of 82,930 that were gathered from 77 studies of 53 centres. Included subjects were apparently healthy, not treated for hypertension or dyslipidaemia, and free from overt CV disease and diabetes. Values of cSBP and amplification were stratified by brachial blood pressure categories and age decade in turn, both being stratified by sex. Amplification decreased with age and more so in males than in females. Sex was the most powerful factor associated with amplification with 6.6 mmHg (5.8-7.4) higher amplification in males than in females. Amplification was marginally but significantly influenced by CVRFs, with smoking and dyslipidaemia decreasing amplification, but increased with increasing levels of blood glucose.

CONCLUSION:

Typical values of cSBP and amplification in a healthy population and a population free of traditional CVRFs are now available according to age, sex, and brachial BP, providing values included from different devices with a wide geographical representation. Amplification is significantly influenced by CVRFs, but differently in men and women.

KEYWORDS:

Adult; Aged; Aorta; Arteries; Arteriosclerosis; Blood pressure; Central pressure; Humans; Pulse

PMID:
25112663
DOI:
10.1093/eurheartj/ehu293
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center