Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell. 2014 Aug 14;158(4):929-944. doi: 10.1016/j.cell.2014.06.049. Epub 2014 Aug 7.

Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin.

Author information

1
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA.
2
Buck Institute for Research on Aging, Novato, CA 94945, USA.
3
Department of Laboratory Medicine, University of California San Francisco, 2340 Sutter St, San Francisco, CA, 94115, USA.
4
The Eli and Edythe Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
5
Research Unit on Biomedical Informatics, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Dr. Aiguader 88, Barcelona 08003, Spain.
6
Department of Biomolecular Engineering, Center for Biomolecular Sciences and Engineering, University of California, Santa Cruz, 1156 High St., Santa Cruz, CA 95064, USA.
7
Department of Computer Science and Center for Computational Molecular Biology, Brown University, 115 Waterman St, Providence RI 02912, USA.
8
The Genome Institute, Washington University, St Louis, MO 63108, USA.
9
National Cancer Institute, NIH, Bethesda, MD 20892, USA.
10
UT MD Anderson Cancer Center, Bioinformatics and Computational Biology, 1400 Pressler Street, Unit 1410, Houston, TX 77030, USA.
11
USC Epigenome Center, University of Southern California Keck School of Medicine, 1450 Biggy Street, Los Angeles, CA 90033, USA.
12
Sage Bionetworks 1100 Fairview Avenue North, M1-C108, Seattle, WA 98109-1024, USA.
13
Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
14
Research Unit on Biomedical Informatics, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Dr. Aiguader 88, Barcelona 08003, Spain; Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluís Companys, 23, Barcelona 08010, Spain.
15
Building 10, Room 4-2732, NIDCD/NIH, 10 Center Drive, Bethesda, MD 20892.
16
Head and Neck Surgery Branch, NIDCD/NIH, 10 Center Drive, Room 5D55, Bethesda, MD 20892.
17
Department of Medicine, University of California San Francisco, 450 35d St, San Francisco, CA, 94148, USA.
18
Buck Institute for Research on Aging, Novato, CA 94945, USA. Electronic address: cbenz@buckinstitute.org.
19
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA. Electronic address: cperou@med.unc.edu.
20
Department of Biomolecular Engineering, Center for Biomolecular Sciences and Engineering, University of California, Santa Cruz, 1156 High St., Santa Cruz, CA 95064, USA. Electronic address: jstuart@ucsc.edu.

Abstract

Recent genomic analyses of pathologically defined tumor types identify "within-a-tissue" disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-of-origin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head and neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pan-cancer subtypes. The multiplatform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All data sets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies.

PMID:
25109877
PMCID:
PMC4152462
DOI:
10.1016/j.cell.2014.06.049
[Indexed for MEDLINE]
Free PMC Article

Publication types, MeSH terms, Grant support

Publication types

MeSH terms

Grant support

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center