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Prog Biophys Mol Biol. 2014 Aug;115(2-3):244-51. doi: 10.1016/j.pbiomolbio.2014.07.011. Epub 2014 Aug 5.

Patient-specific flexible and stretchable devices for cardiac diagnostics and therapy.

Author information

  • 1Biomedical Engineering, Washington University in St Louis, USA.
  • 2Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, USA.
  • 3Biomedical Engineering, Washington University in St Louis, USA. Electronic address: igor@wustl.edu.

Abstract

Advances in material science techniques and pioneering circuit designs have led to the development of electronic membranes that can form intimate contacts with biological tissues. In this review, we present the range of geometries, sensors, and actuators available for custom configurations of electronic membranes in cardiac applications. Additionally, we highlight the desirable mechanics achieved by such devices that allow the circuits and substrates to deform with the beating heart. These devices unlock opportunities to collect continuous data on the electrical, metabolic, and mechanical state of the heart as well as a platform on which to develop high definition therapeutics.

KEYWORDS:

Bioelectronics; Imaging; Physiology

PMID:
25106701
PMCID:
PMC4254044
DOI:
10.1016/j.pbiomolbio.2014.07.011
[PubMed - indexed for MEDLINE]
Free PMC Article
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