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Trends Immunol. 2014 Aug;35(8):353-4. doi: 10.1016/j.it.2014.07.002. Epub 2014 Jul 19.

Regulating the diverse outcomes of interferon's interference.

Author information

1
Department of Immunobiology, Yale University School of Medicine, New Haven 06520, CT, USA.
2
Department of Immunobiology, Yale University School of Medicine, New Haven 06520, CT, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA. Electronic address: susan.kaech@yale.edu.

Abstract

Regulatory T cells are crucial for preventing autoimmunity, but how their function is restrained to allow optimal effector T cells responses in appropriate contexts is unclear. In a recent paper in the Journal of Experimental Medicine, Campbell and colleagues demonstrate that virus-induced type I interferon acts directly on Treg cells to allow for functional antiviral T cell responses.

PMID:
25052591
PMCID:
PMC4267687
DOI:
10.1016/j.it.2014.07.002
[Indexed for MEDLINE]
Free PMC Article

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