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Cell Res. 2014 Oct;24(10):1159-61. doi: 10.1038/cr.2014.91. Epub 2014 Jul 8.

Regeneration: making muscle from hPSCs.

Author information

1
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
2
Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
3
1] National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China [2] Beijing Institute for Brain Disorders, Beijing 100069, China.
4
1] Key Laboratory of Non-coding RNA, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China [2] Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

Abstract

In recent years, researchers worldwide have developed protocols to efficiently differentiate skeletal myogenic cells from human pluripotent stem cells through either ectopic gene expression or the use of small molecules. These stem cell-derived myogenic cells provide new avenues for the study of muscle-related diseases, drug screening and are potentially a new tool for cell therapy against muscular dystrophies.

PMID:
25001388
PMCID:
PMC4185353
DOI:
10.1038/cr.2014.91
[Indexed for MEDLINE]
Free PMC Article

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