Format

Send to

Choose Destination
PLoS One. 2014 Jun 27;9(6):e100760. doi: 10.1371/journal.pone.0100760. eCollection 2014.

Ectosomes: a new mechanism for non-exosomal secretion of tau protein.

Author information

1
Inserm, UMR837, Lille, France; Université de Lille, Faculté de Médecine, IMPRT, JPARC, Lille, France.
2
Inserm, UMR837, Lille, France; Université de Lille, Faculté de Médecine, IMPRT, JPARC, Lille, France; CMRR, CHR, Lille, France.
3
Laboratoire d'Enzymologie et Biochimie Structurales, UPR 3082 CNRS, Gif-sur-Yvette, France.
4
Atomic Energy Commission (CEA), Institute of Biomedical Imaging (I2BM), Molecular Imaging Research Center (MIRCen), Fontenay-aux-Roses, France; CNRS, URA2210, Molecular Imaging Research Center (MIRCen), Fontenay-aux-Roses, France.

Abstract

Tau is a microtubule-associated protein that aggregates in neurodegenerative disorders known as tauopathies. Recently, studies have suggested that Tau may be secreted and play a role in neural network signalling. However, once deregulated, secreted Tau may also participate in the spreading of Tau pathology in hierarchical pathways of neurodegeneration. The mechanisms underlying neuron-to-neuron Tau transfer are still unknown; given the known role of extra-cellular vesicles in cell-to-cell communication, we wondered whether these vesicles could carry secreted Tau. We found, among vesicles, that Tau is predominately secreted in ectosomes, which are plasma membrane-originating vesicles, and when it accumulates, the exosomal pathway is activated.

PMID:
24971751
PMCID:
PMC4074092
DOI:
10.1371/journal.pone.0100760
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Public Library of Science Icon for PubMed Central
Loading ...
Support Center