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Cancer Invest. 2014 Aug;32(7):321-9. doi: 10.3109/07357907.2014.919305. Epub 2014 Jun 6.

Case-control study of breast cancer in India: Role of PERIOD3 clock gene length polymorphism and chronotype.

Author information

1
South Carolina Statewide Cancer Prevention and Control Program,1.

Abstract

BACKGROUND:

This study examined a PERIOD3 (PER3) gene variable number tandem repeat polymorphism and chronotype as potential BrCA risk factors among Indian women.

METHODS:

This case-control study included sporadic, histologically confirmed BrCA cases (n = 255) and controls (n = 249) from India with data collection from 2010-2012.

RESULTS:

Women with the 4/5 or 5/5 PER3 genotype had a nonstatistically significant 33% increased odds of BrCA. Cases were more likely to have a morning (OR = 2.43, 95% CI = 1.23-4.81) or evening (OR = 2.55, 95% CI = 1.19-5.47) chronotype.

CONCLUSIONS:

Findings are consistent with the possibility that extremes in chronotype may elicit circadian desynchronization, resulting in increased BrCA susceptibility.

KEYWORDS:

Breast Cancer; Circadian; Clock Gene; Diurnal Preference

PMID:
24903750
PMCID:
PMC4100474
DOI:
10.3109/07357907.2014.919305
[Indexed for MEDLINE]
Free PMC Article

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