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Kidney Int. 2014 Jun;85(6):1258-60. doi: 10.1038/ki.2013.539.

Decrease of muscle volume in chronic kidney disease: the role of mitochondria in skeletal muscle.

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1
Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Abstract

Reduced muscle volume and impaired exercise endurance are well-documented phenomena in chronic kidney disease, and the relevant molecular mechanisms have been gradually unveiled. Tamaki et al. demonstrate a reduction of mitochondria content in skeletal muscles as a novel mechanism of reduced exercise endurance in renal insufficiency. In addition, they show that a high-protein diet reduces exercise endurance through an inhibition of muscle pyruvate dehydrogenase.

PMID:
24875545
DOI:
10.1038/ki.2013.539
[Indexed for MEDLINE]
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