Send to

Choose Destination
J Expo Sci Environ Epidemiol. 2015 Mar-Apr;25(2):145-52. doi: 10.1038/jes.2014.35. Epub 2014 May 28.

Exploration of the composition and sources of urban fine particulate matter associated with same-day cardiovascular health effects in Dearborn, Michigan.

Author information

Environmental Health Sciences, The University of Michigan, Ann Arbor, Michigan, USA.
Division of Cardiovascular Medicine, The University of Michigan, Ann Arbor, Michigan, USA.
Center for Human Growth and Development and Department of Biostatistics, The University of Michigan, Ann Arbor, Michigan, USA.
Air Quality Division, Michigan Department of Environmental Quality, Lansing, Michigan, USA.
Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, Michigan, USA.
Davis Heart Lung Research Institute, College of Medicine, Ohio State University, Columbus, Ohio, USA.


The objective was to explore associations of chemical components and source factors of ambient fine particulate matter (aerodynamic diameter ≤ 2.5 μm; PM2.5) with cardiovascular (CV) changes following same-day exposure to ambient PM2.5. Twenty-five healthy adults living in rural Michigan were exposed to ambient air in an urban/industrial community for 4 to 5 h daily for five consecutive days. CV health outcomes were measured 1-2 h post exposure. Contributing emission sources were identified via positive matrix factorization. We examined associations between PM2.5 mass, composition and source factors, and same-day changes in CV outcomes using mixed-model analyses. PM2.5 mass (10.8 ± 6.8 μg/m(3)), even at low ambient levels, was significantly associated with increased heart rate (HR). Trace elements as well as secondary aerosol, diesel/urban dust and iron/steel manufacturing factors potentially explained the HR changes. However, trace element analysis demonstrated additional associations with other CV responses including changes in blood pressure (BP), arterial compliance, autonomic balance and trends toward reductions in endothelial function. Two factors were related to BP changes (diesel/urban dust, motor vehicle) and trends toward impaired endothelial function (diesel/urban dust). This study indicates composition of PM2.5 and its sources may contribute to CV health effects independently of PM2.5 mass.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center