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Hum Mol Genet. 2014 Sep 15;23(R1):R27-34. doi: 10.1093/hmg/ddu205. Epub 2014 May 12.

Human-induced pluripotent stem cells pave the road for a better understanding of motor neuron disease.

Author information

1
IZKF Junior Research Group and BMBF Research Group Neuroscience, IZKF, Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Glueckstrasse 6, Erlangen 91054, Germany beate.winner@med.uni-erlangen.de gage@salk.edu.
2
Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
3
Department of Molecular Neurology, Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Schwabachanlage 6, Erlangen 91054, Germany.
4
Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA beate.winner@med.uni-erlangen.de gage@salk.edu.

Abstract

While motor neuron diseases are currently incurable, induced pluripotent stem cell research has uncovered some disease-relevant phenotypes. We will discuss strategies to model different aspects of motor neuron disease and the specific neurons involved in the disease. We will then describe recent progress to investigate common forms of motor neuron disease: amyotrophic lateral sclerosis, hereditary spastic paraplegia and spinal muscular atrophy.

PMID:
24821704
DOI:
10.1093/hmg/ddu205
[Indexed for MEDLINE]

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