Format

Send to

Choose Destination
Ann Med. 2014 Aug;46(5):297-303. doi: 10.3109/07853890.2014.900272. Epub 2014 May 9.

Multiple potential roles for B cells in atherosclerosis.

Author information

1
Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge , Cambridge , UK.

Abstract

The development of atherosclerosis is the major etiological factor causing cardiovascular disease and constitutes a lipid-induced, chronic inflammatory and autoimmune disease of the large arteries. A long-standing view of the protective role of B cells in atherosclerosis has been challenged by recent studies using B cell depletion in animal models. Whereas complete B cell deficiency increases atherosclerosis, depletion of B2 but not B1 cells reduces atherosclerosis. This has led to a re-evaluation of the multiple potential pathways by which B cells can regulate atherosclerosis, and the apparent opposing roles of B1 and B2 cells. B cells, in addition to having the unique ability to produce antibodies, are now recognized to play a number of important roles in the immune system, including cytokine production and direct regulation of T cell responses. This review summarizes current knowledge on B cell subsets and functions, and how these could distinctly influence atherosclerosis development.

KEYWORDS:

Atherosclerosis; immunity; lymphocytes

PMID:
24813455
DOI:
10.3109/07853890.2014.900272
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center