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J Nutr Metab. 2014;2014:202759. doi: 10.1155/2014/202759. Epub 2014 Mar 25.

Nutrigenomics: definitions and advances of this new science.

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Universidade Anhembi Morumbi/Gerência de Nutrição Enteral e Parenteral, Rua Pedro Ivo 22, 01323-070 São Paulo, SP, Brazil.
BioLife Brasil Ltda, Distrito Agroindustrial de Formosa, Quadra 01, Lote 15, 73801-970 Formosa, GO, Brazil.
Gerência de Nutrição Enteral e Parenteral-GANEP, Rua Pedro Ivo 22, 01323-070 São Paulo, SP, Brazil.


The search for knowledge regarding healthy/adequate food has increased in the last decades among the world population, researchers, nutritionists, and health professionals. Since ancient times, humans have known that environment and food can interfere with an individual's health condition, and have used food and plants as medicines. With the advance of science, especially after the conclusion of the Human Genome Project (HGP), scientists started questioning if the interaction between genes and food bioactive compounds could positively or negatively influence an individual's health. In order to assess this interaction between genes and nutrients, the term "Nutrigenomics" was created. Hence, Nutrigenomics corresponds to the use of biochemistry, physiology, nutrition, genomics, proteomics, metabolomics, transcriptomics, and epigenomics to seek and explain the existing reciprocal interactions between genes and nutrients at a molecular level. The discovery of these interactions (gene-nutrient) will aid the prescription of customized diets according to each individual's genotype. Thus, it will be possible to mitigate the symptoms of existing diseases or to prevent future illnesses, especially in the area of Nontransmissible Chronic Diseases (NTCDs), which are currently considered an important world public health problem.

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