Format

Send to

Choose Destination
J Int Med Res. 2014 Jun;42(3):702-10. doi: 10.1177/0300060513505813. Epub 2014 Apr 23.

Association between interleukin 10 gene polymorphisms and risk of type 2 diabetes mellitus in a Chinese population.

Author information

1
Department of Endocrinology, First Affiliated Hospital of the People's Liberation Army, Beijing, China.
2
Department of Pathology, General Hospital of the People's Liberation Army, Beijing, China.
3
Department of Endocrinology, First Affiliated Hospital of the People's Liberation Army, Beijing, China shinanyang677@126.com.

Erratum in

  • J Int Med Res. 2014 Oct;42(5):1189.

Abstract

OBJECTIVE:

To investigate the relationship between the interleukin 10 (IL10) gene single nucleotide polymorphisms (SNP) -1082 G/A (rs1800896), -819 T/C (rs1800871) and -592 A/C (rs1800872) and risk of type 2 diabetes mellitus in a Chinese population.

METHODS:

This case-control study recruited patients with type 2 diabetes mellitus and healthy control subjects. Genotyping of the -1082 G/A (rs1800896), -819 T/C (rs1800871) and -592 A/C (rs1800872) SNPs was conducted and genotype frequencies were compared between the two groups.

RESULTS:

The study recruited 364 patients with type 2 diabetes mellitus and 677 healthy controls. Patients carrying the -1082 GG genotype had a significantly increased risk of type 2 diabetes mellitus (adjusted odds ratio [OR] 1.57, 95% confidence interval [CI] 1.03, 2.68), as did those patients carrying the -592 AA genotype (adjusted OR 1.63, 95% CI 1.06, 2.53). Subjects carrying both the -1082 GA + GG and -592 AC + AA genotypes had a significantly increased risk of type 2 diabetes mellitus (adjusted OR 2.03, 95% CI 1.24, 3.15).

CONCLUSIONS:

The SNPs -1082G/A and -592 A/C increased the risk for type 2 diabetes mellitus, and could be potential targets for screening for the early detection of the risk of type 2 diabetes mellitus.

KEYWORDS:

IL10 gene; Interleukin 10; polymorphism; predictive markers; type 2 diabetes mellitus

PMID:
24758873
DOI:
10.1177/0300060513505813
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center