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Cell Res. 2014 Jun;24(6):641-2. doi: 10.1038/cr.2014.51. Epub 2014 Apr 18.

A chemical approach to "rewire" neural progenitor cells.

Author information

1
Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd., La Jolla, CA 92037, USA.
2
1] National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China [2] Beijing Institute for Brain Disorders, Beijing 100875, China.

Abstract

Generation of neural progenitor cells (NPCs) from pluripotent stem cells including ESCs and iPSCs and derivation of NPCs from somatic tissues have been considered promising approaches that could be used therapeutically to restore function in patients suffering neurodegenerative diseases. A new study published in Cell Research shows, for the first time, the generation of NPCs from somatic cells by small molecule compounds under hypoxia without exogenous transcription factors.

PMID:
24743789
PMCID:
PMC4042174
DOI:
10.1038/cr.2014.51
[Indexed for MEDLINE]
Free PMC Article

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