A case of lepromatous leprosy complicated by hemophagocytosis misdiagnosed as hemophagocytic lymphohistiocytosis

Int J Infect Dis. 2014 Jun:23:28-30. doi: 10.1016/j.ijid.2014.02.004. Epub 2014 Mar 18.

Abstract

Leprosy is an infectious chronic granulomatous disease caused by Mycobacterium leprae. The disease mainly affects the skin, peripheral nerves, mucosa, and viscera. The World Health Organization has reported that most countries with high endemicity have reached the goal of eliminating leprosy (defined as reaching a prevalence of <1 leprosy case per 10 000 population) at the national level, after years of proactive control campaigns. The incidence of leprosy has been decreasing across the globe year by year. However, misdiagnosis happens occasionally due to the complexity of clinical manifestations and lack of physician awareness of this disease. We report a case of lepromatous leprosy complicated by hemophagocytosis misdiagnosed as hemophagocytic lymphohistiocytosis.

Keywords: Hemophagocytic lymphohistiocytosis; Hemophagocytosis; Lepromatous leprosy; Misdiagnosis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Dexamethasone / therapeutic use
  • Diagnostic Errors*
  • Hematologic Diseases / complications
  • Hematologic Diseases / diagnosis*
  • Hematologic Diseases / drug therapy
  • Humans
  • Leprosy, Lepromatous / complications
  • Leprosy, Lepromatous / diagnosis*
  • Leprosy, Lepromatous / drug therapy
  • Levofloxacin / therapeutic use
  • Lymphohistiocytosis, Hemophagocytic / diagnosis*
  • Male
  • Treatment Outcome

Substances

  • Levofloxacin
  • Dexamethasone