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J Am Geriatr Soc. 2014 Apr;62(4):667-72. doi: 10.1111/jgs.12740. Epub 2014 Mar 17.

"IDEAL" aging is associated with lower resting metabolic rate: the Baltimore Longitudinal Study of Aging.

Author information

1
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland; Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.

Abstract

OBJECTIVES:

To assess the associations among age, health status, and resting metabolic rate (RMR) in a large population of older adults.

DESIGN:

Cross-sectional analysis.

SETTING:

Community-dwelling volunteers from the Baltimore Longitudinal Study of Aging (BLSA).

PARTICIPANTS:

Persons aged 40 to 96 (mean 68.2 ± 11.0) who underwent a comprehensive physical examination, cognitive assessment, RMR testing, body composition assessment, and physical function testing during a 3-day clinic visit (N = 420).

MEASUREMENTS:

Participants were assigned to Insight into the Determination of Exceptional Aging and Longevity (IDEAL) or non-IDEAL categories based on health status. IDEAL participants were defined according to the absence of physical and cognitive impairments, chronic conditions and comorbidities, and blood profile abnormalities. A three-stage linear regression model was used to assess the relationship between RMR and age, using IDEAL classification as a predictor and adjusting for sex and body composition.

RESULTS:

Resting metabolic rate averaged 1,512.4 ± 442.9 kcal/d and was lower with older age (β = -8.55, P < .001). After adjusting for age, sex, and body composition, RMR was 109.6 kcal/d lower in IDEAL than non-IDEAL participants (P < .005).

CONCLUSION:

Individuals who are fully functional and free of major medical conditions have lower RMR than those with disease and functional impairments. These findings suggest that health status plays a role in energy use and regulation independent of age and body composition and that elevated RMR may be a global biomarker of poor health in older persons.

KEYWORDS:

aging; comorbidities; resting metabolic rate

PMID:
24635835
PMCID:
PMC3989425
DOI:
10.1111/jgs.12740
[Indexed for MEDLINE]
Free PMC Article

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