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J Biol Chem. 2014 Apr 18;289(16):10950-7. doi: 10.1074/jbc.C113.533968. Epub 2014 Mar 7.

A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining.

Author information

1
From the Department of Chemistry and Chemical Biology and.

Abstract

The recent discovery of numerous human short open reading frame (sORF)-encoded polypeptides (SEPs) has raised important questions about the functional roles of these molecules in cells. Here, we show that a 69-amino acid SEP, MRI-2, physically interacts with the Ku heterodimer to stimulate DNA double-strand break ligation via nonhomologous end joining. The characterization of MRI-2 suggests that this SEP may participate in DNA repair and underscores the potential of SEPs to serve important biological functions in mammalian cells.

KEYWORDS:

DNA Repair; Peptide Interactions; Peptides; Protein-Protein Interactions; Proteomics; Short ORF

PMID:
24610814
PMCID:
PMC4036235
DOI:
10.1074/jbc.C113.533968
[Indexed for MEDLINE]
Free PMC Article

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