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Curr Biol. 2014 Mar 3;24(5):R206-8. doi: 10.1016/j.cub.2014.01.027.

Aging: it's SIRTainly possible to restore mitochondrial dysfunction.

Author information

1
Departments of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
2
Departments of Pathology, Yale School of Medicine, New Haven, CT 06520, USA; Genetics, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address: Gerald.Shadel@yale.edu.

Abstract

Mitochondrial dysfunction is strongly associated with aging. A recent study shows that reduced nuclear SIRT1 activity initiates age-related mitochondrial decline through a signaling pathway that perturbs expression of genes encoded by mitochondrial DNA. This reversible pathway has potential anti-aging therapeutic value.

PMID:
24602889
DOI:
10.1016/j.cub.2014.01.027
[Indexed for MEDLINE]
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