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Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4173-8. doi: 10.1073/pnas.1400350111. Epub 2014 Mar 4.

Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5.

Author information

1
Department of Molecular Virology, Immunology and Medical Genetics and Department of Anesthesiology, Wexner Medical Center, and Department of Neurological Surgery, The Ohio State University, Columbus, OH 43210.

Abstract

The mechanism by which the 8q24 MYC enhancer region, including cancer-associated variant rs6983267, increases cancer risk is unknown due to the lack of protein-coding genes at 8q24.21. Here we report the identification of long noncoding RNAs named cancer-associated region long noncoding RNAs (CARLos) in the 8q24 region. The expression of one of the long noncoding RNAs, CARLo-5, is significantly correlated with the rs6983267 allele associated with increased cancer susceptibility. We also found the MYC enhancer region physically interacts with the active regulatory region of the CARLo-5 promoter, suggesting long-range interaction of MYC enhancer with the CARLo-5 promoter regulates CARLo-5 expression. Finally, we demonstrate that CARLo-5 has a function in cell-cycle regulation and tumor development. Overall, our data provide a key of the mystery of the 8q24 gene desert.

PMID:
24594601
PMCID:
PMC3964128
DOI:
10.1073/pnas.1400350111
[Indexed for MEDLINE]
Free PMC Article

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