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J Turk Ger Gynecol Assoc. 2013 Sep 1;14(3):130-5. doi: 10.5152/jtgga.2013.02679. eCollection 2013.

Does Aquaporin-1 expression have clinical significance in serous epithelial ovarian cancer?

Author information

1
Department of Obstetrics and Gynecology, Division of Gynecological Oncology, Başkent University School of Medicine, Ankara, Turkey.
2
Department of Pathology, Başkent University School of Medicine, Ankara, Turkey.

Abstract

in English, Turkish

OBJECTIVE:

To assess the relationship between Aquaporin-1 (AQP1) expression and clinicopathological variables in serous epithelial ovarian cancer (EOC).

MATERIAL AND METHODS:

Serous EOC cases treated in our institution between January 2007 and December 2009 were included in the study. A semi-quantitative immunohistochemical method was used to determine AQP1 expression levels, intratumoral microvessel density (IMD) and AQP1/IMD ratios. The relationship between these parameters and clinicopathological variables were assessed. P values less than 0.05 was considered statistically significant.

RESULTS:

A total of 55 cases of serous EOC were included in the study. AQP1 was strongly expressed in the membranes of microvessels and small vessels within all tumor tissues. In a few cases, AQP1 expression was also observed in the membrane of interstitial cells and in individual tumor cells. A positive correlation was detected between preoperative CA125 levels and the expression of AQP1 (R: 0.277, p<0.05). AQP1 expression was similar between FIGO stage I-II and FIGO stage III-IV cases (p > 0.05). A significant relationship did not exist between AQP1 expression and FIGO stage, lymph node metastasis or ascites volume (p>0.05).

CONCLUSION:

In this study, AQP1 expression did not have a significant association with important clinicopathological variables in serous EOC. Future studies are needed to determine AQP1 expression in other histological types of EOC.

KEYWORDS:

Aquaporin-1; intratumoral microvessel density; serous epithelial ovarian cancer

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