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J Turk Ger Gynecol Assoc. 2012 Dec 1;13(4):227-32. doi: 10.5152/jtgga.2012.35. eCollection 2012.

C-reactive protein and lipoprotein-a as markers of coronary heart disease in polycystic ovary syndrome.

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Department of Obstetrics and Gynecology, İstanbul Bilim University Avrupa Florence Nightingale Hospital, İstanbul, Turkey.


in English, Turkish


The aim of this study was to investigate the risk factors of coronary heart disease, CRP and Lipoprotein-a in polycystic ovary syndrome patients.


Prospectively collected data of polycystic ovary syndrome patients (n=62) and control group (n=40) were compared.


PCOS patients had higher HOMA-IR, CRP, DHEAS, free testosterone, FAI, LH and prolactin levels when compared to the control group. Lipoprotein-a levels did not differ between the groups. The obese PCOS group had statistically significantly higher fasting blood glucose, total cholesterol, triglyceride, free testosterone, insulin, CRP and HOMA-IR and statistically significantly lower HDL and SHBG when compared to normal weight PCOS persons. Fasting blood glucose, total cholesterol, LDL, SHBG, CRP, Lipoprotein-a, FSH, LH, TSH, DHEAS and prolactin levels did not differ between the normal weight and obese control groups.


CRP levels increase in polycystic ovary syndrome patients and can be used as a marker of coronary heart disease. Future studies can be directed at treatments to decrease CRP levels, including antiinflammatory treatments.


CRP; Polycystic ovary syndrome; coronary heart disease; lipoprotein-a; obesity

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